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Resource Type: Journal Article Resource Type: Journal Article Resource Type: Journal Article

Prophylactic magnesium sulphate in prevention of eclampsia in women with severe preeclampsia: randomised controlled trial (PIPES trial)

Optimum dose, route and duration of use of prophylactic magnesium sulphate in women with severe pre-eclampsia are still unclear. This study compared the efficacy and safety of 'low-dose Dhaka' regime with 'Loading dose only' regime for seizure prophylaxis in severe pre-eclampsia using a randomised controlled trial in 402 women in Bangladesh.

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Resource Type: Journal Article

Serum amyloid A, procalcitonin, highly sensitive C reactive protein and tumor necrosis factor alpha levels and acute inflammatory response in patients with hemolysis, elevated liver enzymes, low platelet count (HELLP) and eclampsia

The aim of this study was to determine the relationship between serum amyloid A (SAA), procalcitonin (ProC), highly sensitive C reactive protein (hsCRP) and tumor necrosis factor (TNF) alpha activity in patients with pre-eclampsia, eclampsia and hemolysis, elevated liver enzymes, low platelet count (HELLP), and the pathogenesis and severity of the disease.

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Resource Type: Brief Nigeria

Findings from post-intervention analysis of pre-eclampsia/eclampsia in Kogi State, Nigeria

This study brief describes a pre/post, cross-sectional design with both qualitative and quantitative data collected at baseline (2015) and endline (2018). Data collection activities include in-depth interviews with policy makers, survivors of pre-eclampsia and eclampsia (PE/E), and laboratory workers; focus group discussions with men and women from the community; and surveys and observations of client-provider interactions to assess provider capacity in antenatal care and facility readiness and capacity to identify, treat, and manage PE/E at the primary and secondary levels.

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Resource Type: Brief Nigeria

Findings from post-intervention analysis of pre-eclampsia/eclampsia in Ebonyi State, Nigeria

This study briefs describes a pre/post, cross-sectional design with qualitative and quantitative data collected at baseline (2015) and endline (2018). Data collection activities include in-depth interviews with policy makers, survivors of PE/E and laboratory professionals; focus group discussions  with men and women from the community; and surveys and observations to assess provider capacity in antenatal care and facility readiness and capacity to identify, treat, and manage pre-eclampsia and eclampsia at the primary and secondary levels.

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Resource Type: Brief Nigeria

Findings from post-intervention analysis of pre-eclampsia and eclampsia in Cross River State, Nigeria

Maternal and newborn deaths due to pre-eclampsia and eclampsia (PE/E) are preventable, yet in Nigeria this is the most significant direct cause of maternal mortality. Following a landscape analysis to better understand the enormity of this problem across seven states in Nigeria, a cross-cutting intervention was implemented in Cross River, Ebonyi, and Kogi states. Researchers worked with primary health care (PHC) providers, policy makers, women’s groups, and community members to increase uptake of underutilized interventions and commodities for the prevention and treatment of PE/E in rural Nigeria. Follow-up analysis occurred in each state.

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Resource Type: Bangladesh Brief Ethiopia Kenya Nigeria Pakistan

Primary Health Care-Preeclampsia/Eclampsia Plus Model

Between 2008 and 2014, the Council conducted an implementation research study to evaluate task shifting around the prevention, detection, and management of pre-eclampsia and eclampsia (PE/E) at the primary health care (PHC) level, hereby defined as the PHC PE/E Core Model. The study showed that not only were PHC providers effectively able to carry out this task, but maternal mortality in the intervention group decreased. Core model components included training PHC providers on detection and management of PE/E, administration of a loading dose of MgSO4, referral of women to secondary facilities for monitoring, and reinforcing proper detection and management of PE/E at secondary facilities.

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Resource Type: Brief Nigeria

Engaging women’s groups for improved uptake of antenatal services in Cross River State, Nigeria: An analysis of post-intervention findings

The Ending Eclampsia project aimed to understand the potential of underutilized and promising interventions that increase access to services, particularly improving community referral systems. In Nigeria’s Cross River State, this study tested the feasibility of women’s group leaders delivering health information for PE/E, referral, and other antenatal care (ANC) services to their peers, to increasing access to quality maternal and newborn health services.

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Resource Type: Brief Nigeria

Assessing the feasibility and acceptability of community health extension workers to treat hypertension associated with pregnancy: An analysis of post-intervention findings

This study tested the feasibility of tasking community health extension workers (CHEWs) with detecting and managing hypertension, and prescribing an oral antihypertensive drug – alpha methyldopa (aldomet) – at primary health care (PHC) facilities as part of a package of care for women with pre-eclampsia/eclampsia (PE/E). This evaluation measured improvements in knowledge retention and increases in early detection, prevention, and management of PE/E.

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