Diabetes and pre-eclampsia affecting pregnancy: a retrospective cross-sectional study
Journal of Investigative Medicine, 2017
Results showed that regardless of diabetes status, patients with pre-eclampsia delivered prematurely. Patients in the group with pre-eclampsia and pregestational diabetes delivered much earlier, when compared with the patients that had pre-eclampsia with gestational diabetes and pre-eclampsia with no diabetes. Additionally, patients with pre-existing diabetes who developed pre-eclampsia delivered smaller babies than those with pre-existing diabetes without pre-eclampsia. Pre-existing diabetes with added insult of pre-eclampsia led to fetal growth restriction. This outcome validates the understanding that elevated glucose earlier in pregnancy alters placentogenesis and leads to fetal growth restriction.