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Resource Type: Journal Article

Drugs for treating severe hypertension in pregnancy: A network meta-analysis and trial sequential analysis of randomized clinical trials

British Journal of Clinical Pharmacology, 2018

This network meta-analysis suggests similar efficacy nifedipine, hydralazine, and labetalol in the treatment of severe hypertension in pregnancy. The above drugs may also be useful in treating hypertension in severe pre-eclampsia. Moderate quality of evidence was observed for direct comparison pooled estimate between labetalol and hydralazine but was either low or very low for other comparisons. Negligible differences were observed in the individual safety profile. The cumulative evidence is inadequate for any meaningful conclusion for other drugs.

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