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Resource Type: Journal Article

Screening and management of preeclampsia and eclampsia in antenatal and labor and delivery services: findings from cross-sectional observation studies in six sub-Saharan African countries

This study highlighted notable deficiencies in six countries in relation to pre-eclampsia and eclampsia (PE/E) screening and treatment, which are echoed in findings from the literature. Findings from these studies suggest the majority of women attending antenatal care and labor and delivery services are not screened according to WHO-recommended standards.

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Resource Type: Brief

Antihypertensive drugs for high blood pressure in pregnancy

Despite being safe, low-cost, effective, and commonly
available, antihypertensive drugs may not be available to women and families who need them. However, members
of Maternal Health Caucus of the Reproductive Health Supplies
Coalition agree antihypertensive drugs should be part of the
essential medicines list for maternal health.

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Resource Type: Journal Article Resource Type: Journal Article Resource Type: Journal Article

Prophylactic magnesium sulphate in prevention of eclampsia in women with severe preeclampsia: randomised controlled trial (PIPES trial)

Optimum dose, route and duration of use of prophylactic magnesium sulphate in women with severe pre-eclampsia are still unclear. This study compared the efficacy and safety of 'low-dose Dhaka' regime with 'Loading dose only' regime for seizure prophylaxis in severe pre-eclampsia using a randomised controlled trial in 402 women in Bangladesh.

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Resource Type: Journal Article

Serum amyloid A, procalcitonin, highly sensitive C reactive protein and tumor necrosis factor alpha levels and acute inflammatory response in patients with hemolysis, elevated liver enzymes, low platelet count (HELLP) and eclampsia

The aim of this study was to determine the relationship between serum amyloid A (SAA), procalcitonin (ProC), highly sensitive C reactive protein (hsCRP) and tumor necrosis factor (TNF) alpha activity in patients with pre-eclampsia, eclampsia and hemolysis, elevated liver enzymes, low platelet count (HELLP), and the pathogenesis and severity of the disease.

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Resource Type: Brief Nigeria

Findings from post-intervention analysis of pre-eclampsia/eclampsia in Kogi State, Nigeria

This study brief describes a pre/post, cross-sectional design with both qualitative and quantitative data collected at baseline (2015) and endline (2018). Data collection activities include in-depth interviews with policy makers, survivors of pre-eclampsia and eclampsia (PE/E), and laboratory workers; focus group discussions with men and women from the community; and surveys and observations of client-provider interactions to assess provider capacity in antenatal care and facility readiness and capacity to identify, treat, and manage PE/E at the primary and secondary levels.

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Resource Type: Brief Nigeria

Findings from post-intervention analysis of pre-eclampsia/eclampsia in Ebonyi State, Nigeria

This study briefs describes a pre/post, cross-sectional design with qualitative and quantitative data collected at baseline (2015) and endline (2018). Data collection activities include in-depth interviews with policy makers, survivors of PE/E and laboratory professionals; focus group discussions  with men and women from the community; and surveys and observations to assess provider capacity in antenatal care and facility readiness and capacity to identify, treat, and manage pre-eclampsia and eclampsia at the primary and secondary levels.

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Resource Type: Brief Nigeria

Findings from post-intervention analysis of pre-eclampsia and eclampsia in Cross River State, Nigeria

Maternal and newborn deaths due to pre-eclampsia and eclampsia (PE/E) are preventable, yet in Nigeria this is the most significant direct cause of maternal mortality. Following a landscape analysis to better understand the enormity of this problem across seven states in Nigeria, a cross-cutting intervention was implemented in Cross River, Ebonyi, and Kogi states. Researchers worked with primary health care (PHC) providers, policy makers, women’s groups, and community members to increase uptake of underutilized interventions and commodities for the prevention and treatment of PE/E in rural Nigeria. Follow-up analysis occurred in each state.

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Resource Type: Bangladesh Brief Ethiopia Kenya Nigeria Pakistan

Primary Health Care-Preeclampsia/Eclampsia Plus Model

Between 2008 and 2014, the Council conducted an implementation research study to evaluate task shifting around the prevention, detection, and management of pre-eclampsia and eclampsia (PE/E) at the primary health care (PHC) level, hereby defined as the PHC PE/E Core Model. The study showed that not only were PHC providers effectively able to carry out this task, but maternal mortality in the intervention group decreased. Core model components included training PHC providers on detection and management of PE/E, administration of a loading dose of MgSO4, referral of women to secondary facilities for monitoring, and reinforcing proper detection and management of PE/E at secondary facilities.

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